KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRKCA
All Species:
19.09
Human Site:
T176
Identified Species:
38.18
UniProt:
P17252
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P17252
NP_002728.1
672
76764
T176
A
D
E
K
L
H
V
T
V
R
D
A
K
N
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001096447
673
76980
L176
D
R
D
V
L
I
V
L
V
R
D
A
K
N
L
Dog
Lupus familis
XP_548026
590
67545
F145
N
P
Q
W
N
E
S
F
T
F
K
L
K
P
S
Cat
Felis silvestris
Mouse
Mus musculus
P20444
672
76833
T176
T
D
E
K
L
H
V
T
V
R
D
A
K
N
L
Rat
Rattus norvegicus
P05696
672
76773
T176
T
D
E
K
L
H
V
T
V
R
D
A
K
N
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510097
675
76844
T177
T
G
E
K
L
Q
V
T
V
R
D
A
K
N
L
Chicken
Gallus gallus
NP_001012822
674
76827
T176
T
G
D
K
L
E
V
T
V
R
E
A
K
N
L
Frog
Xenopus laevis
Q7LZQ8
671
76506
T173
K
E
E
V
M
T
V
T
V
G
D
A
K
N
L
Zebra Danio
Brachydanio rerio
Q90XF2
588
67303
G158
T
D
R
I
W
G
L
G
R
Q
G
Y
K
C
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P05130
679
77676
Q194
K
E
N
L
L
T
V
Q
I
K
E
G
R
N
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P90980
682
77982
K178
E
N
D
Q
L
T
I
K
I
L
E
A
K
N
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
P87253
1142
127954
K600
Q
K
K
T
H
K
D
K
A
S
S
M
S
E
R
Conservation
Percent
Protein Identity:
100
N.A.
80.2
86.7
N.A.
98.3
99.4
N.A.
97.1
93.9
78.4
34.6
N.A.
67.1
N.A.
66.4
N.A.
Protein Similarity:
100
N.A.
88.8
87.1
N.A.
98.8
99.6
N.A.
98.2
96.7
87
52.2
N.A.
80.7
N.A.
79.7
N.A.
P-Site Identity:
100
N.A.
60
6.6
N.A.
93.3
93.3
N.A.
80
66.6
60
13.3
N.A.
26.6
N.A.
33.3
N.A.
P-Site Similarity:
100
N.A.
66.6
13.3
N.A.
93.3
93.3
N.A.
80
80
73.3
33.3
N.A.
60
N.A.
73.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
25.3
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
38.3
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
0
0
0
0
9
0
0
67
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% C
% Asp:
9
34
25
0
0
0
9
0
0
0
50
0
0
0
0
% D
% Glu:
9
17
42
0
0
17
0
0
0
0
25
0
0
9
0
% E
% Phe:
0
0
0
0
0
0
0
9
0
9
0
0
0
0
0
% F
% Gly:
0
17
0
0
0
9
0
9
0
9
9
9
0
0
0
% G
% His:
0
0
0
0
9
25
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
9
0
9
9
0
17
0
0
0
0
0
9
% I
% Lys:
17
9
9
42
0
9
0
17
0
9
9
0
84
0
0
% K
% Leu:
0
0
0
9
67
0
9
9
0
9
0
9
0
0
75
% L
% Met:
0
0
0
0
9
0
0
0
0
0
0
9
0
0
0
% M
% Asn:
9
9
9
0
9
0
0
0
0
0
0
0
0
75
0
% N
% Pro:
0
9
0
0
0
0
0
0
0
0
0
0
0
9
0
% P
% Gln:
9
0
9
9
0
9
0
9
0
9
0
0
0
0
0
% Q
% Arg:
0
9
9
0
0
0
0
0
9
50
0
0
9
0
9
% R
% Ser:
0
0
0
0
0
0
9
0
0
9
9
0
9
0
9
% S
% Thr:
42
0
0
9
0
25
0
50
9
0
0
0
0
0
0
% T
% Val:
0
0
0
17
0
0
67
0
59
0
0
0
0
0
0
% V
% Trp:
0
0
0
9
9
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _